Palmitoylethanolamide（544-31-0） has miraculous skincare effects

1) Porduct profile

Palmitoylethanolamide （CAS 544-31-0）is an amide compound included 16 carbon ‘s palmitic acid （see the following）. 

2) Usage in cosmetic

From the report of American Personal Care Products Council, PEA has the function of Surfactants-Foam Booster, Viscosity Increasing Agents-Aqueous. Similarly, Korean Cosmetic Association(KCA) describes PEA’s effect as Surfactants and Viscosity Increasing Agents-Aqueous (as the following ). 

3) Skincare mechanism

PEA indirectly could activate the receptor Cannabinoid (CB). PEA is known to have anti-inflammatory, analgesic, and neuroprotective properties. PEA supplements have been used by people with chronic pain as well as those with neuropathic pain. According to patent literature 1(US6503492B2), adding PEA powder to deodorant or antiperspirant, pruritus induced by histamine is decreased, IL-6 (inflammation index) also is reduced. From another patent literature(US9623000 B2), adding PEA powder to hydrocortisone, which could be treat inflammation diseases. As mentioned above, there are many literature to prove that PEA has the effect of anti-inflammation, analgesic as well as skin calming. 

4) Formulation

According to the relevant researches, Palmitoylethanolamide can be dissolved in solvents pentanediol, hexanediol and butanediol. These cosmetics mixtures has the effects of skin calming, anti-inflammation and enhancing immunity. And the mixtures could be make various formulations, such as toner, latex, cream, gel, cosmetics powder. 

5) Further pharma profile

Wuxi Further Pharmaceutical Co., Ltd is an innovation-driven and service-oriented pharmaceutical hi-tech company. Its’ international trading department mainly specializes in exporting a variety of API, pharmaceutical intermediates, food additives and dietary supplements etc.